Analysis of noncoding regulatory mutations in cancer
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3101.html
An interesting report of potential non-coding drivers without actually doing any wet lab work.
“These methods identify recurrent mutations in regulatory elements upstream of PLEKHS1, WDR74 and SDHD, as well as previously identified mutations in the TERT promoter”. In the text they mention “Khurana et al. also reported WDR74 promoter mutations in 2 of the 20 prostate cancer genomes analyzed”.